Graphite web is a public web server for the analysis and visualization of biological pathways using high-throughput gene expression data. It supports five different gene set analysis, three species and two databases of pathways. Graphite web has a powerful pathway visualization that makes results interpretation easily accessible to the user.

The grouping of genes into functionally related entities, such as biological pathways, is of great help for interpreting the results obtained from gene expression experiments, moving the attention from the study of individual genes to that of groups of genes. The aim of this type of analyses is to identify groups of genes with coordinated expression changes differentiating biological conditions.

Graphite web supports competitive and independent, topological and non-topological gene set methods to unravel the complexity of cellular regulatory mechanisms.

Sample analyses on TCGA Colon Cancer Dataset Stage III vs Stage II:

• GSEA - KEGG
• GSEA - Reactome
• CliPPER - KEGG
• CliPPER - Reactome